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Nefiracetam API powder
Nefiracetam API Powder: Uses, Specifications, Research and Buyers
Nefiracetam API powder is a research compound from the pyrrolidone family. It has attracted interest in neuroscience and pharmaceutical research. Researchers have studied it for cognitive and neurological applications.
Nefiracetam is also known as DM-9384. Its CAS number is 77191-36-7. PubChem lists its molecular formula as C14H18N2O2. Its molecular weight is 246.30 g/mol.
The compound has been investigated for memory-related conditions. Research has included Alzheimer’s disease and stroke-related neurological problems. However, research findings should not be confused with approved medical indications.
For businesses, nefiracetam API powder can therefore interest pharmaceutical researchers. It may also interest laboratories studying cognitive pharmacology.
What Is Nefiracetam API Powder?
Nefiracetam is a synthetic pyrrolidone-type compound. It belongs to a group of compounds studied for effects on brain function.
The chemical name is N-(2,6-dimethylphenyl)-2-(2-oxopyrrolidin-1-yl)acetamide. PubChem identifies the compound under several chemical databases.
The term API means active pharmaceutical ingredient. However, API status does not automatically mean that a substance has marketing approval.
In commercial research, the term can describe a high-purity chemical intended for further pharmaceutical development. Therefore, buyers should verify the intended regulatory status before purchase or use.
Nefiracetam research has focused on cognition, memory, neurotransmission, and neurological function. Early studies reported effects in several animal models of memory impairment.
Nefiracetam Chemical Profile
The basic chemical profile is important for identification and quality control.
| Specification | Nefiracetam |
|---|---|
| Chemical name | N-(2,6-dimethylphenyl)-2-(2-oxopyrrolidin-1-yl)acetamide |
| Common name | Nefiracetam |
| Development code | DM-9384 |
| CAS Number | 77191-36-7 |
| Molecular formula | C14H18N2O2 |
| Molecular weight | 246.30 g/mol |
| Chemical class | Pyrrolidone derivative |
| Physical form | Solid / powder |
| Primary research area | Neuroscience |
| Research focus | Cognition and memory |
| Purity target | Buyer-specific specification |
| Intended application | Research and development |
The molecular information above comes from PubChem.
For commercial procurement, buyers should request a current Certificate of Analysis (CoA). They should also request analytical data such as HPLC results.
Depending on the application, buyers may request additional testing. This can include NMR, LC-MS, residual solvents, water content, and elemental analysis.
What Is Nefiracetam Used For?
Nefiracetam has mainly been studied in neurological and cognitive research. Scientists have investigated its possible effects on learning and memory.
Animal studies reported improvements in some experimental models of amnesia. For example, researchers studied nefiracetam in scopolamine-related learning impairment.
Other research examined its effects on memory impairment in older rabbits. The study investigated whether nefiracetam could improve associative learning.
Researchers have also investigated possible cellular mechanisms. These studies examined cholinergic and GABAergic transmission. They also examined neuronal calcium signaling.
Therefore, common research keywords include nefiracetam cognitive research, nefiracetam memory research, and DM-9384 neuroscience research.
Nefiracetam and Cognitive Research
One important research area involves learning and memory.
Researchers have studied nefiracetam in animal models involving impaired cognition. Some experiments reported improved performance after administration of the compound.
These findings helped generate interest in further pharmaceutical research. However, animal results cannot establish human clinical effectiveness.
Research has also examined possible interactions with neurotransmitter systems. In particular, studies have explored cholinergic and GABA-related mechanisms.
Another publication examined NMDA receptor function and CaMKII signaling. The authors proposed mechanisms that could contribute to cognitive effects.
Consequently, nefiracetam remains relevant to experimental neuroscience.
Nefiracetam Research in Alzheimer’s Disease
Alzheimer’s disease has been one of the major research areas associated with nefiracetam.
PubChem records nefiracetam as having been studied in trials involving Alzheimer’s disease.
Older scientific literature also described nefiracetam as a cognition-enhancing drug under investigation. Researchers examined whether it could address memory impairment.
However, historical development does not establish current approval. Buyers should therefore distinguish between research use and an approved pharmaceutical indication.
This distinction matters when selling or purchasing nefiracetam API powder.
A professional product page should avoid unsupported claims. It should also avoid describing nefiracetam as a proven treatment for Alzheimer’s disease.
Instead, suitable descriptions include:
- Research compound
- Neuroscience research material
- Pharmaceutical development compound
- Cognitive pharmacology research material
- Laboratory research API
These descriptions provide useful information without overstating the evidence.
Nefiracetam and Stroke Research
Researchers have also investigated nefiracetam following stroke.
One randomized clinical study examined nefiracetam for poststroke depression. The study included 159 patients and compared nefiracetam with placebo. The researchers did not find it effective as a general treatment for poststroke depression.
Another study examined poststroke apathy. The trial compared nefiracetam with placebo in stroke patients.
The researchers reported no significant overall difference between groups. The study also highlighted its very small randomized sample.
Earlier research reported different findings in selected patient groups. One study examined apathy among patients with poststroke depression.
These differences demonstrate why clinical evidence needs careful interpretation.
Nefiracetam should therefore be presented as an investigational research compound. It should not be marketed as an established stroke treatment.
Who Buys Nefiracetam API Powder?
The potential buyers of nefiracetam depend on local regulations and intended use.
The most relevant buyers are usually organizations involved in scientific research. These organizations may require analytical-grade or research-grade material.
Pharmaceutical Research Companies
Pharmaceutical companies may investigate nefiracetam during early-stage research. They may study its pharmacology, formulation, or biological activity.
Such buyers often require detailed technical documentation.
Typical documents include a CoA, specification sheet, SDS, and analytical results.
Contract Research Organizations
CROs can purchase research compounds for pharmaceutical clients. Their work may involve pharmacology, analytical testing, or formulation research.
For these buyers, consistency between batches can be especially important.
They may therefore request defined specifications and batch documentation.
Universities and Research Institutes
Academic laboratories can also purchase nefiracetam for neuroscience studies.
Researchers may investigate receptor activity, neuronal signaling, cognition, or experimental memory models.
Universities usually require appropriate documentation before accepting research chemicals.
API Distributors and Chemical Importers
Specialized chemical distributors may purchase nefiracetam for laboratory customers.
These buyers often focus on batch quality, packaging, documentation, and regulatory compliance.
They may also request different quantities for different research programs.
Nefiracetam API Powder Quality Control
Quality control is essential when sourcing pharmaceutical research chemicals.
A reliable supplier should provide batch-specific documentation. The CoA should identify the compound and report analytical results.
A typical specification package can include the following:
| Quality parameter | Typical buyer requirement |
|---|---|
| Appearance | White to off-white solid |
| Identification | Conforms by analytical method |
| Assay | Buyer-defined specification |
| HPLC purity | Buyer-defined specification |
| Water content | Reported by validated method |
| Residual solvents | Reported against specification |
| Heavy metals | Where applicable |
| Melting point | Reported reference value |
| Storage | Controlled conditions |
| Packaging | Sealed research-chemical packaging |
These values should not be treated as universal specifications.
The final specification should come from the actual manufacturing batch. It should also match the buyer’s intended application.
For high-value procurement, buyers can request third-party testing. This can provide additional confidence in identity and purity.
How to Buy Nefiracetam API Powder
Professional buyers should begin by defining the required specification.
They should then confirm the CAS number. For nefiracetam, the commonly listed CAS number is 77191-36-7.
Next, buyers should request a current CoA. The CoA should correspond to the supplied batch.
Buyers should also request an SDS. This document provides important handling and safety information.
For international transactions, regulatory requirements should be checked before shipment. Rules can differ between countries and product classifications.
The supplier should also confirm packaging and storage conditions.
For larger orders, buyers may request a sample first. This allows their laboratory to perform independent testing.
Only after successful verification should buyers proceed with larger procurement.
Nefiracetam API Powder: Important Considerations
Nefiracetam has an interesting history in pharmaceutical research.
Scientific studies have investigated memory, cognition, neurotransmission, and stroke-related conditions. Some preclinical studies reported promising effects.
However, human clinical results have been mixed.
For example, one poststroke depression study did not find nefiracetam effective overall.
Likewise, a later poststroke apathy trial found no significant overall benefit.
Therefore, responsible product information should focus on research rather than unsupported medical claims.
For commercial buyers, quality and documentation remain central considerations.
A professional supplier should provide traceable batches. It should also provide suitable analytical documentation.
Conclusion
Nefiracetam API powder is a synthetic pyrrolidone-derived research compound. Its CAS number is 77191-36-7, and its molecular weight is 246.30 g/mol.
Researchers have studied nefiracetam in cognitive and neurological research. Studies have explored memory, learning, neurotransmission, and stroke-related conditions.
However, research findings do not automatically establish clinical efficacy. Buyers should therefore distinguish research applications from approved medical uses.
Potential buyers include pharmaceutical research companies, CROs, universities, laboratories, and specialized chemical distributors.
For procurement, buyers should verify identity, purity, batch consistency, documentation, and local regulatory requirements.
The best sourcing approach combines analytical verification with clear technical specifications.
References
- PubChem. Nefiracetam, CID 71157. Chemical identity, formula, molecular weight, CAS number, and identifiers.
- Luthman J. et al. Effects of nefiracetam on brain monoamine systems. PubMed.
- Robinson RG. et al. Double-blind randomized treatment of poststroke depression using nefiracetam. PubMed.
- Starkstein SE. et al. Randomized study of nefiracetam for poststroke apathy. PubMed.
- Pak J. et al. Nefiracetam and associative learning impairment. PubMed.
- Yoshii M. et al. Cellular mechanisms underlying cognition-enhancing actions of nefiracetam. PubMed.
- Pharmacological research on nefiracetam and NMDA receptor signaling. PubMed.
